When one of Gotham’s most sinister villains, Roman Sionis, and his sadistic right-hand Zsasz, put a target on a young girl named Cass, the city’s most wicked underbelly is turned upside down looking for her. Harley, Huntress, Canary and Renee Montoya’s paths collide, and the unlikely foursome have no choice but to team up to take Roman Down.